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KMID : 0383820070630030294
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Tuberculosis and Respiratory Diseases
2007 Volume.63 No. 3 p.294 ~ p.298
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A Case of Pulmonary Alveolar Proteinosis with Spontaneous Resolution
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Nam Seung-Bum
Kim Hyo-Seok
Kim Chul-Hyun
Lee Jae-Chul
Lee Ho-Jin
Jeong Jae-Wook
Park Kwang-Young
Choi Yoon-Hee
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Abstract
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Pulmonary alveolar proteinosis is a rare disorder that is characterized by the abundant accumulation of surfactant-derived material within the alveolar spaces and distal bronchioles. Although the findings of homogenous ground-glass opacities overlaid by thickened septa, which form a "crazy paving" pattern on high-resolution computed tomography, can assist in making a diagnosis, a lung biopsy is usually required. This disorder has a variable clinical course, from spontaneous resolution to respiratory failure and death. While a whole lung lavage has been the standard treatment since the early 1960s, GM-CSF therapy has been attempted based on the recently suggested pathogenetic mechanism. We report a case of pulmonary alveolar proteinosis that resolved spontaneously after an open lung biopsy.
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KEYWORD
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Pulmonary alveolar proteinosis, Spontaneous resolution
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